Trans-nerolidol, one of the powerhouses in our CALM formula, is one of the 200+ volatile aromatic compounds called terpenes that create the unique flavors and aromas of plants and different cannabis strains. Each terpene also has unique therapeutic properties. Trans-nerolidol has a woody, fruity, citrus aroma reminiscent of citrus, apples and roses. Many botanicals contain high levels of trans-nerolidol, including lemongrass, jasmine, tea tree, ginger and neroli (an essential oil distilled from bitter orange flowers).
Trans-nerolidol produces potent cognitive effects and has been traditionally used for its relaxing, slightly sedative effects. Additionally, researchers suspect this terpene may ease anxiety without altering motor skills. A 2016 study published in the Indian Journal of Pharmacology examined the effects of trans-nerolidol on oxidative stress in neuronal cells. The mice exposed to this terpene displayed high levels of sedation and showed lower levels of stress.
In addition to its anti-anxiety properties, nerolidol calms with slight sedative effects. Widespread anecdotal evidence supports this, along with a 2013 study published in the journal Neurochemical Research revealed that nerolidol appeared to have both a sedative and antioxidant effect on rodent test subjects.
Not only does this powerful terpene assist with stress and anxiety, nerolidol has also been shown to be an antioxidant, antibacterial, antimicrobial, and antibiotic, it has even arrested the growth of cancer cells in some studies.